本硕授课课程: 讲授本科生课程:《生物工程设备》、《生物工程设备课程设计》、《分子生物学与基因工程》、《生物工程分析与检验》、《认识实习》 讲授研究生课程:《生物统计学》、《发酵过程优化与控制》 纵向课题: 1. 国家自然科学基金青年基金,22308180,全细胞催化合成2,5-呋喃二甲酸的关键酶及底物转运机制研究,2024.01-2026.12,30万元,主持; 2. 山东省自然科学基金青年基金,ZR2020QB041,5-羟甲基糠醛氧化还原酶HmfH的催化机制及其制备2,5-呋喃二甲酸的研究,2021.01-2023.12,15万元,主持; 3. 必赢唯一官方网站生物及生物化学ESI学科开放课题,No.202018,5-羟甲基糠醛氧化还原酶催化制备2,5-呋喃二甲酸的机制研究,2020.09-2022.08,10万元,主持; 4. 生物基材料与绿色造纸国家重点实验室自主研究课题,ZZ20190314,2,5-呋喃二甲酸的单酶法制备研究,2019.12-2021.12,5万元,主持; 5. 国家自然科学基金青年基金,31600068,代谢工程改造枯草芽孢杆菌合成N-乙酰神经氨酸关键问题的研究,2017.01-2019.12,21万元,参与; 6. 山东省重点研发计划(重大科技创新工程),2022CXGC010506,一步混菌发酵制备维生素C,2022.02-2025.02,1000万元,参与。 主要论文: [1] Haibo Yuan, Jianghua Li, Hyun-dong Shin, Guocheng Du, Jian Chen, Zhongping Shi*, Long Liu. Improved production of 2,5-furandicarboxylic acid by overexpression of 5-hydroxymethylfurfural oxidase and 5-hydroxymethylfurfural/furfural oxidoreductase in Raoultella ornithinolytica BF60[J]. Bioresource Technology, 2018, 247: 1184-1188. [2] Haibo Yuan, Yanfeng Liu, Jianghua Li, Hyun-dong Shin, Guocheng Du, Zhongping Shi*, Jian Chen, Long Liu*. Combinatorial synthetic pathway fine-tuning and comparative transcriptomics for metabolic engineering of Raoultella ornithinolytica BF60 to efficiently synthesize 2,5-furandicarboxylic acid[J]. Biotechnology and Bioengineering, 2018, 115(9): 2148-2155. [3] Wenhu Chen#, Qian Liu#, Meng Liu, Hongling Liu, Di Huang, Yi Jiang, Tengfei Wang*, Haibo Yuan*. Symbiosis mechanism of associated bacteria on 2-keto-L-gulonic acid production via mixed fermentation: A Review[J]. Fermentation, 2023, 9(12):1000. [4] Haibo Yuan, Hongling Liu, Jieke Du, Kaiquan Liu, Tengfei Wang*, Long Liu*. Biocatalytic production of 2,5-furandicarboxylic acid: recent advances and future perspectives[J]. Applied Microbiology and Biotechnology, 2020, 104(2): 527-543. [5] Haibo Yuan, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Zhongping Shi*, Long Liu*. Enhanced 2, 5-furandicarboxylic acid (FDCA) production in Raoultella ornithinolytica BF60 by manipulation of the key genes in FDCA biosynthesis pathway[J]. Journal of Microbiology and Biotechnology, 2018, 28(12): 1999-2008. [6] Zekun Tao#, Haibo Yuan#, Meng Liu, Qian Liu, Siyi Zhang, Hongling Liu, Yi Jiang, Di Huang, Tengfei Wang*. Yeast Extract: Characteristics, Production, Applications and Future Perspectives[J]. Journal of Microbiology and Biotechnology, 2023, 33(2):151-166. [7] Hanyu Cong#, Haibo Yuan#, Zekun Tao, Hanlin Bao, Zheming Zhang, Yi Jiang, Di Huang, Hongling Liu, Tengfei Wang*. Recent Advances in Catalytic Conversion of Biomass to 2,5-Furandicarboxylic Acid[J]. Catalysts, 2021, 11, 1113. [8] Ping Lin#, Haibo Yuan#, Jieke Du, Kaiquan Liu, Hongling Liu*, Tengfei Wang*. Progress in research and application development of surface display technology using Bacillus subtilis spores[J]. Applied Microbiology and Biotechnology, 2020, 104(6):2319-2331. 发明专利(第一发明人): 一株解淀粉芽孢杆菌及其在制备2,5-呋喃二甲酸中的应用,ZL202210010919.3; 一种7α-HSDH酶突变体和7β-HSDH酶突变体及其编码基因和应用,202310494882.0。 |