盛文龙副研究员

姓    名

盛文龙

性    别

男

籍    贯

山东莒县

出生年月

1988.12

职    称

副研究员

政治面貌

中共党员

专    业

神经生物学

职    务

科研科副科长（正科级）

导师类别

硕士生导师

学历、学位

研究生、博士

课 题 组

药物筛选研究室

工作信息

邮箱：shengwenlong1121@163.com

隶属单位

必赢唯一官方网站（山东省科学院）生物研究所

通讯地点

济南市历城区经十东路28789号

学习、工作简历：

2019.01至今       必赢唯一官方网站（山东省科学院）生物研究所    助理研究员、副研究员

 （其间2019.03—2020.07借调至省科技厅，2021.06—2022.07挂职任商河县科技副县长）

2016.08—2019.01   山东省科学院生物研究所   助理研究员

2011.09—2016.06   复旦大学神经生物学专业（硕博连读）   导师杨雄里院士

主要研究方向：1. 物质活性筛选与安全性评价；2. 荧光探针应用研究；3. 视网膜信息处理的神经机制及分子生物学基础。

科研项目：

1.  不同种属动物视网膜中褪黑素差异调控生物节律的机制研究，省自然科学基金面上项目，主持。

2.  褪黑素受体在昼行动物斑马鱼视网膜中的表达及对自感光神经节细胞光反应的调制，省自然科学基金，主持。

3.  检测过氧化物的荧光探针制备及其活性与安全性评价，校（院）科教产融合试点工程基础研究类项目，主持。

4.  山东省科学院人才专项（A类优秀博士引进），主持。

5.  褪黑素受体在昼行动物斑马鱼和鸽子视网膜中的细胞学定位，省科学院青年科学基金，主持。

6.  山东省科学院科技发展基金项目，主持。

7.  局域性视网膜损伤所致的视路异常及功能重塑机制研究，国家自然科学基金重点项目，参与。

8.  光遗传学解析视网膜内层抑制性环路，国家自然科学基金面上项目，参与。

9.  基于斑马鱼模型研究重金属镉对耳石发育的毒性效应及机制，国家自然科学基金青年基金，参与。

10.  山东道地药材活性成分样品库的构建及创新药物研究，山东省重点研发计划（重大科技创新工程项目），参与。

11.  用于孕期营养补充的固态特医食品制备关键技术及产品研发，山东省重点研发计划（医用食品专项计划），参与。

12.  基于高值转化技术的海参副产物新产品研发及产业化示范，山东省重点研发计划，参与。

13.  抗癫痫药物高效筛选技术研发与应用，济南市“新高校20条”科研带头人工作室，参与。

14.  神经保护天然活性成分的筛选及功能产品研发，济南市“新高校20条”引进高端人才项目，参与。

15.  山东省人类疾病斑马鱼模型与药物筛选工程技术研究中心，济南市“新高校20条”科技创新平台，参与。

16.  心血管疾病常用中药功效组分辨识与质量评价技术研究，济南市“新高校20条”创新团队项目，参与。

17.  基于斑马鱼模型评价一种新材料的多种生物活性，技术服务合同（工程科研项目），主持。

18.  化合物生物活性检测及安全性评价，技术服务合同（工程科研项目），主持。

19.  EPS1120P/EPS1121P/EPS1122P三种蛋白样品抑制血管生成活性研究，技术服务合同（工程科研项目），主持，。

20.  基于斑马鱼模型比较不同生产工艺的阿胶样品的补血活性差异，技术服务合同（工程科研项目），主持。

21.  不同干燥方式引起的紫河车防治贫血症状的异同，技术服务合同（工程科研项目），主持。

22. 博士生科研经费，复旦大学，主持。

学术论文：

发表第一作者或通讯作者SCI论文60余篇（含1区30篇）

1.Hanchuang Zhu, Mengyuan Liu, Caiyun Liu, Miaohui Yu, Kun, Wang, Xinke Li, Wenlong Sheng, Baocun Zhu, Portable ratiometric fluorescence analytical device for copper ions based on smartphone in environment and living organisms, Science of The Total Environment, 2023, 857, 159448. （IF=9.8，共同通讯作者，1区）

2.Caiyun Liu, Xiaodi Rong, Xiwei Li, Na Gao, Leyang Qu, Yiyuan Peng, Jiafan Shi, Miaohui Yu, Wenlong Sheng, Baocun Zhu, Monitoring GSH dynamics under drug intervention in HepG2 cells and visualizing the engrafted liver cancer in zebrafish with a glycyrrhetinic acid-based reversible fluorescent probe, Sensors and Actuators B-Chemical, 2023, 389, 133841. （IF=8.4，共同通讯作者，1区）

3.Caiyun Liu, Xin Wang, Hanchuang Zhu, Kun Wang, Miaohui Yu, Yan Zhang, Meijun Su, Xiaodi Rong, Wenlong Sheng, Baocun Zhu, Multifunctional Theranostic Probe Based on the Pim-1 Kinase Inhibitor with the Function of Tracking pH Fluctuations during Treatment, Analytical Chemistry. 2023, 95, 11732-11740.（IF=7.4，共同通讯作者，1区）

4.Miaohui Yu, Tingting Fu, Wenzhai Li, Yan Zhang, Huayan Wen, Min Zheng, Moran Shi, Caiyun Liu, Meng Jin, Kechun Liu, Lei Cai, Baocun Zhu, Wenlong Sheng, A specific amino-based fluorescent probe for mercury ions detection in water samples, cells and zebrafish, New Journal of Chemistry, 2023, （IF=3.3，通讯作者，3区）

5.Miaohui Yu, Zhongzhuang Qian, Moran Shi, Tingting Fu, Wenzhai Li, Xin Wang, Xiaoqi Zhang, Qian Yu, Zeji Li, Caiyun Liu, Xiao Li, Jun Qi, Kechun Liu, Baocun Zhu, Lei Cai, Wenlong Sheng, Mitochondrial targeting fluorescent probe for specific detection of nickel ions and biological imaging, Journal of Photochemistry and Photobiology A-Chemistry, 2023, 444, 114912.（IF=4.3，通讯作者，3区）

6.Mengyuan Liu, Hanchuang Zhu, Yikun Fang, Caiyun Liu, Xinke Li, Xiaohui Zhang, Lixue Ma , Kun Wang, Miaohui Yu, Wenlong Sheng, Baocun Zhu, An ultra-sensitive fluorescent probe for recognition of aluminum ions and its application in environment, food, and bio-imaging, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 307, 123578.（IF=4.4，共同通讯作者，2区）

7.Caiyun Liu, Xiwei Li, Xiaodi Rong, Mingzhu Li, Miaohui Yu, Wenlong Sheng, Baocun Zhu, The rational utilization of organelle microenvironment for imaging of lysosomal SO2 with high fidelity, Analytica Chimica Acta, 2023, 1267, 341338. （IF=6.2，共同通讯作者，1区）

8.Mengyuan Liu, Hanchuang Zhu, Kun Wang, Xiaohui Zhang, Xinke Li, Miaohui Yu, Baocun Zhu, Wenlong Sheng, Caiyun Liu, A Novel Fluorescent Chemodosimeter for Discriminative Detection of Cu2+ in Environmental, Food, and Biological Samples, ACS Food Science and Technology, 2023, 3, 1, 134–140. （共同通讯作者）

9.Caiyun Liu, Yan Zhang, Weimin Sun, Hanchuang Zhu, Meijun Su, Xin Wang, Xiaodi Rong, Kun Wang, Miaohui Yu, Wenlong Sheng, Baocun Zhu, H2S-activated fluorescent probe enables dual-channel fluorescence tracking of drug release in tumor cell, Bioorganic Chemistry, 2023, 135, 106498. （IF=5.1，共同通讯作者，1区）

10.Caiyun Liu, Yan Zhang, Weimin Sun, Hanchuang Zhu, Meijun Su, Xin Wang, Xiaodi Rong, Kun Wang, Miaohui Yu, Wenlong Sheng, Baocun Zhu, A novel GSH-activable theranostic probe containing kinase inhibitor for synergistic treatment and selective imaging of tumor cells, Talanta, 2023, 260, 124567. （IF=6.1，共同通讯作者，1区）

11.Wenlong Sheng, Miaohui Yu, Xue Wang, Meng Jin, Xiangming Pang, Can Li, Shanshan Zhang, Peihai Li, Xixin Wang, Changqing Zhang, Yun Zhang, Kechun Liu, Localization of Neuropeptide Receptor NPY4R in Rat Retina, Neuropeptides, 2022, 93, 102246.（IF=2.9，第一作者、通讯作者，3区）

12.Xin Wang, Caiyun Liu, Hanchuang Zhu, Siyu Cheng, Yan Zhang, Meijun Su, Xiaodi Rong, Miaohui Yu, Wenlong Sheng, Baocun Zhu, An ultra-sensitive and highly selective fluorescent probe for nickel ions and its enironmental and biological applications, Sensors and Actuators B-Chemical, 2022, 369, 132300. （IF=8.4，共同通讯作者，1区）

13.Hanchuang Zhu, Xue Zhang, Caiyun Liu, Yan Zhang, Meijun Su, Xiaodi Rong, Xin Wang, Mengyuan Liu, Xiaohui Zhang, Wenlong Sheng, BaocunZhu, A reversible NIR fluorescent probe for monitoring of SO2 and formaldehyde in live cells and zebrafish, Sensors and Actuators B-Chemical, 2022, 366, 131962. （IF=8.4，共同通讯作者，1区）

14.Meijun Su, Caiyun Liu, Yuying Liang, Yan Zhang, Xiaodi Rong, Xin Wang, Xiwei Li, Kun Wang, Hanchuang Zhu, Miaohui Yu, Wenlong Sheng, Baocun Zhu, A novel water-soluble naphthalimide-based turn-on fluorescent probe for mercury ion detection in living cells and zebrafish, New Journal of Chemistry, 2022, 46, 10951-10956. （IF=3.3，共同通讯作者，3区）

15.Yan Zhang, Caiyun Liu, Weimin Sun, Ziwen Yu, Meijun Su, Xiaodi Rong, Xin Wang, Kun Wang, Xiwei Li, Hanchuang Zhu, Miaohui Yu, Wenlong Sheng, Baocun Zhu, Concise Biothiol-Activatable HPQ-NBD Conjugate as a Targeted Theranostic Probe for Tumor Cells, Analytical Chemistry. 2022, 94, 7140-7147.（IF=7.4，共同通讯作者，1区）

16.Hanchuang Zhu, Caiyun Liu, Xiaodi Rong, Yan Zhang, Meijun Su, Xin Wang, Mengyuan Liu, Xiaohui Zhang, Wenlong Sheng, Baocun Zhu, A new isothiocyanate-based Golgi-targeting fluorescent probe for Cys and its bioimaging applications during the Golgi stress response, Bioorganic Chemistry, 2022, 122, 105741. （IF=5.1，共同通讯作者，1区）

17.Xin Wang, Siyu Cheng, Caiyun Liu, Yan Zhang, Meijun Su, Xiaodi Rong, Hanchuang Zhu,   Miaohui Yu, Wenlong Sheng, Baocun Zhu, Discovery of a highly selective and ultra-sensitive colorimetric fluorescent probe for malononitrile and its applications in living cells and zebrafish, New Journal of Chemistry, 2022,46, 1713-1719. （IF=3.3，共同通讯作者，3区）

18.Kun Wang, Yilin Liu, Caiyun Liu, Hanchuang Zhu, Xiwei Li, Miaohui Yu, Lunying Liu, Guoqing Sang, Wenlong Sheng, Baocun Zhu, A new-type HOCl-activatable fluorescent probe and its applications in water environment and biosystems, Science of the Total Environment, 2022, 839, 156164.（IF=9.8，共同通讯作者，1区）

19.Xin Wang, Siyu Cheng, Caiyun Liu, Yan Zhang, Meijun Su, Xiaodi Rong, Hanchuang Zhu, Miaohui Yu, Wenlong Sheng, Baocun Zhu, A novel ratiometric fluorescent probe for the detection of nickel ions in the environment and living organisms, Science of the Total Environment, 2022, 840, 156445.（IF=9.8，1区, 共同通讯作者）

20.Yan Zhang，Caiyun Liu，Meijun Su，Xiaodi Rong，Xin Wang，Kun Wang，Xiwei Li，Hanchuang Zhu，Miaohui Yu，Wenlong Sheng，Baocun Zhu, A highly selective barbiturate-based fluorescent probe for detecting Hg2+ in cells and zebrafish as well as in real water samples, Journal of Photochemistry and Photobiology A-Chemistry, 2022, 113706. （IF=4.3，共同通讯作者，3区）

21.Xiaodi Rong, Yiyuan Peng, Caiyun Liu, Mingzhu Li, Jiafan Shi, Miaohui Yu, Shuaikang Ba,   Wenlong Sheng, Baocun Zhu, A novel highly sensitive fluorescent probe for imaging endogenous CO, New Journal of Chemistry, 2022, 46, 23096-23101. （IF=3.3，共同通讯作者，3区）

22.Lizhen Wang, Wenlong Sheng, Zhaoshun Tan, Qingyu Ren, Rongchun Wang, Rostyslav Stoika, Xuedong Liu, Kechun Liu, Xueliang Shang, Meng Jin，Treatment of Parkinson's disease in Zebrafish model with a berberine derivative capable of crossing blood brain barrier, targeting mitochondria, and convenient for bioimaging experiments, Comparative Biochemistry and Physiology C-Toxicology & Pharmacology,  2021, 249, 109151. （IF=3.9，共同第一作者，2区）

23.Wenlong Sheng; Shijun Weng; Fei Li; Yun Zhang; Qiuxia He; Wenxiang Sheng; Ying Fu; Haiyue Yan; Kechun Liu, Immunohistological Localization of Mel1a Melatonin Receptor in Pigeon Retina, Nature and Science of Sleep, 2021, 13, 113-121. （IF=3.4，第一作者，3区）

24.Wenlong Sheng, Xue Zhang, Miaohui Yu, Meng Jin, Ning Li, Chen Sun, Lizhen Wang, Qing Xia, Xiaobin Li, Yun Zhang, Baocun Zhu, Kechun Liu, A novel cell membrane-targeting fluorescent probe for imaging endogenous/exogenous formaldehyde in live cells and zebrafish. Analyst, 2021,146，7554-7562. （IF=4.2，第一作者，2区）

25.Wenlong Sheng, Kun Wang, Na Gao, Lizhen Wang, Rongchun Wang, Xuanming Zhang, Xiqiang Chen, Yun Zhang, Baocun Zhu, Kechun Liu, A novel p-dimethylaminophenylether-based fluorescent probe for detecting native ONOO− in cells and zebrafish, Analyst, 2021, 146, 5264-5270.（IF=4.2，第一作者，2区）

26.Wenlong Sheng, Yamin Yu, Na Gao, Meng Jin, Ning Li, Lizhen Wang, Can Li, Huili Zhang,   Yun Zhang, Kechun Liu. An ultrasensitive ratiometric fluorescent probe for the detection of Hg2+ and its application in cell and zebrafish. Analytical Methods, 2021, 13, 1043-1048. （IF=3.1，第一作者、通讯作者，3区）

27.Yamin Yu, Wenlong Sheng, Caiyun Liu, Na Gao, Bin Tian, Hanchuang Zhu, Pan Jia, Zilu Li, Xue Zhang, Kun Wang, Xiwei Li, Baocun Zhu. A simple sensitive ratiometric fluorescent probe for the detection of mercury ions in living cells and zebrafish. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 2021, 249, 119279. （IF=4.4，共同第一作者，2区）

28.Mei Zhao, YuShuang Guo, GuoDong Fu, Qiong Wang, Wenlong Sheng, DianShun Guo. Development of a Si-rhodamine-based NIR fluorescence probe for highly specific and quick response of Hg2+ and its applications to biological imaging. Microchemical Journal. 2021, 171, 106855. （IF=4.8，共同通讯作者，2区）

29.Hanchuang Zhu, Changxu Liang, Xinyu Cai, Hanming Zhang, Caiyun Liu, Pan Jia, Zilu Li, Yamin Yu, Xue Zhang, Wenlong Sheng, Baocun Zhu. Rational Design of a Targetable Fluorescent Probe for Visualizing H2S Production under Golgi Stress Response Elicited by Monensin. Analytical Chemistry, 2020, 92, 1883-1889.（IF=7.4，共同通讯作者，1区）

30.Hanchuang Zhu, Caiyun Liu, Changxu Liang, Bin Tian, Hanming Zhang, Xue Zhang, Wenlong Sheng, Yamin Yu, Shengyun Huang, Baocun Zhu. A new phenylsulfonamide-based Golgi-targeting fluorescent probe for H2S and its bioimaging applications in living cells and zebrafish. Chemical Communications. 2020, 56, 4086-4089.（IF=4.9，共同通讯作者，2区）

31.Pan Jia，Dongmei Liu，Zihan Zhuang，Leyang Qu，Caiyun Liu，Yongfang Zhang，Zilu Li，Hanchuang Zhu，Yamin Yu，Xue Zhang，Wenlong Sheng，Baocun Zhu. A highly selective ratiometric fluorescence probe for bioimaging of hypobromous acid in living cells and zebrafish. Sensors and Actuators B-Chemical. 2020, 320, 128583. （IF=8.4，共同通讯作者，1区）

32.Xiwei Li, Qingxia Duan, Yamin Yu, Kun Wang, Hanchuang Zhu, Xue Zhang, Caiyun Liu, Pan Jia, Zilu Li, Wenlong Sheng, Baocun Zhu. A coumarin-based fluorescent probe for Hg2+ and its application in living cells and zebrafish. Luminescence. 2020, 35: 941-946.（IF=2.9，共同通讯作者，4区）

33.Kun Wang, Pan Jia, Xiwei Li, Xue Zhang, Caiyun Liu, Yamin Yu, Hanchuang Zhu, Zilu Li, Wenlong Sheng, Baocun Zhu. A simple p-methylaminophenylether-based fluorescent probe for detecting native hypochlorous acid in live cells and zebrafish. Dyes and Pigments, 2020, 177, 108310. （IF=4.5，共同通讯作者，1区）

34.Yamin Yu, Caiyun Liu, Bin Tian, Xinyu Cai, Hanchuang Zhu, Pan Jia, Zilu Li, Xue Zhang, Wenlong Sheng, Baocun Zhu. A novel highly selective ratiometric fluorescent probe with large emission shift for detecting mercury ions in living cells and zebrafish. Dyes and Pigments, 2020, 177  108290. （IF=4.5，共同通讯作者，1区）

35.Xue Zhang, Caiyun Liu, Xinyu Cai, Bin Tian, Hanchuang Zhu, Yanan Chen, Wenlong Sheng, Pan Jia, Zilu Li, Yamin Yu, Shengyun Huang , Baocun Zhu. A highly specific Golgi-targetable fluorescent probe for tracking cysteine generation during the Golgi stress response. Sensors and Actuators B-Chemical, 2020, 310, 127820. （IF=8.4，共同通讯作者，1区）

36.Xue Zhang, Caiyun Liu, Yanan Chen, Xinyu Cai, Wenlong Sheng, Hanchuang Zhu, Pan Jia, Zilu Li, Shengyun Huang, Baocun Zhu. Visualization of cysteine level during Golgi stress with a novel targeting highly specific fluorescent probe. Chemical Communications. 2020, 56, 1807-1810（IF=4.9，共同通讯作者，2区）

37.Zilu Li, Chen Yu, Yanan Chen, Zihan Zhuang, Bin Tian, Caiyun Liu, Pan Jia, Hanchuang Zhu, Yamin Yu, Xue Zhang, Wenlong Sheng, Baocun Zhu. A novel Pd2+-free highly selective and ultrasensitive fluorescent probe for detecting CO-releasing molecule-2 in live cells and zebrafish. Dyes and Pigments, 2020, 174, 108040. （IF=4.5，共同通讯作者，1区）

38.Xue Zhang, Yanan Chen, Xinyu Cai, Caiyun Liu, Pan Jia, Zilu Li, Hanchuang Zhu, Yamin Yu, Kun Wang, Xiwei Li, Wenlong Sheng, Baocun Zhu. A highly sensitive rapid-response fluorescent probe for specifically tracking endogenous labile Fe2+ living cells and zebrafish. Dyes and Pigments, 2020, 174, 108065. （IF=4.5，共同通讯作者，1区）

39.Pan Jia, Zihan Zhuang, Caiyun Liu, Zuokai Wang, Qingxia Duan, Zilu Li, Hanchuang Zhu, Fenfen Zhang, Wenlong Sheng, Baocun Zhu. Development of a ratiometric fluorescent probe with a large emission shift for imaging ONOO- in live cells and zebrafish. Dyes and Pigments, 2020, 173, 107942. （IF=4.5，共同通讯作者，1区）

40.Pan Jia, Zihan Zhuang, Dongmei Liu, Yanan Chen, Bin Tian, Caiyun Liu, Zilu Li, Hanchuang Zhu, Yamin Yu, Xue Zhang, Wenlong Sheng, Shengyun Huang, Baocun Zhu. A novel highly selective fluorescent probe for imaging endogenous hypobromous acid in living cells and zebrafish. Sensors and Actuators B-Chemical, 2020, 305, 127460. （IF=8.4，共同通讯作者，1区）

41.Hanchuang Zhu , Caiyun Liu , Hanming Zhang , Pan Jia , Zilu Li , Xue Zhang , Yamin Yu , Wenlong Sheng , Baocun Zhu, A Simple Long-wavelength Fluorescent Probe for Simultaneous Discrimination of Cysteine/Homocysteine and Glutathione/Hydrogen Sulfide with Two Separated Fluorescence Emission Channels by Single Wavelength Excitation, Analytical Sciences. 2020, 36(2):255-262. （IF=1.6，共同第一作者，4区）

42.Zuokai Wang, Caiyun Liu, Xin Wang, Qingxia Duan, Pan Jia, Hanchuang Zhu, Zilu Li, Xue Zhang, Xiaohua Ren, Baocun Zhu, Wenlong Sheng. A metal-free near-infrared fluorescent probe for tracking the glucose-induced fluctuations of carbon monoxide in living cells and zebrafish. Sensors and Actuators B-Chemical, 2019, 291 329-336. （IF=8.4，共同通讯作者，1区）

43.Caiyun Liu, Zilu Li, Chen Yu, Yanan Chen, Dongmei Liu, Zihan Zhuang, Pan Jia, Hanchuang Zhu, Xue Zhang, Yamin Yu, Baocun Zhu, Wenlong Sheng. Development of a concise rhodamine-formylhydrazine type fluorescent probe for highly specific and ultrasensitive tracing of basal HOCl in live cells and zebrafish. ACS Sensors. 2019 4, 2156-2163. （IF=8.9, 共同通讯作者，1区）

44.Caiyun Liu, Qingxia Duan, Xue Zhang, Zilu Li, Pan Jia, Hanchuang Zhu, Yamin Yu, Zuokai Wang, Baocun Zhu, Wenlong Sheng. A novel hepatoma-specific fluorescent probe for imaging endogenous peroxynitrite in live HepG2 cells. Sensors and Actuators B-Chemical, 2019, 289, 124-130. （IF=8.4, 共同通讯作者，1区）

45.Wenlong Sheng, Meng Jin, Ge Pan, Shijun Weng, Attila Sik, Liwen Han, Kechun Liu. Cellular localization of melatonin receptor Mel1b in pigeon retina. Neuropeptides, 2019, 78, 101974.  （IF=2.9, 第一作者、通讯作者，3区）

46.Caiyun Liu, Pan Jia, Zihan Zhuang, Zuokai Wang, Qingxia Duan, Zilu Li, Hanchuang Zhu, Xue Zhang, Baocun Zhu, Wenlong Sheng. A water-soluble and highly specific fluorescent probe with large stokes shift for imaging basal HOCl in living cells and zebrafish. Sensors and Actuators B- Chemical, 2019, 291, 243-249. （IF=8.4，共同通讯作者，1区）

47.Qingxia Duan, Pan Jia, Zihan Zhuang, Caiyun Liu, Xue Zhang, Zuokai Wang, Wenlong Sheng, Zilu Li, Hanchuang Zhu, Baocun Zhu, Xiaoling Zhang. Rational design of a hepatoma-specific fluorescent probe for HOCl and its bioimaging applications in living HepG2 cells. Analytical Chemistry, 2019, 91, 2163-2168.（IF=7.4，共同通讯作者，1区）

48.Qingxia Duan, Hanchuang Zhu, Caiyun Liu, Ruifang Yuan, Zhaotong Fang, Zuokai Wang, Pan Jia, Zilu Li, Wenlong Sheng, Baocun Zhu. A carbonothioate-based far-red fluorescent probe for the specific detection of mercury ions in living cells and zebrafish. Analyst, 2019, 144, 1426-1432.（IF=4.2，共同通讯作者，2区）

49.Qingxia Duan, Xiaoyu Lv, Caiyun Liu, Zhuofan Geng, Fenfen Zhang, Wenlong Sheng, Zuokai Wang, Pan Jia, Zilu Li, Hanchuang Zhu, and Baocun Zhu. Dichlororesorufin-Based Colorimetric and Fluorescent Probe for Ultrasensitive Detection of Mercury Ions in Living Cells and Zebrafish. Industrial & Engineering Chemistry Research, 2019, 58, 11-17.（IF=4.2，共同通讯作者，3区）

50.Zuokai Wang, Ziyang Zhao, Caiyun Liu, Zhuofan Geng, Qingxia Duan, Pan Jia, Zilu Li, Hanchuang Zhu, Baocun Zhu, Wenlong Sheng. A long-wavelength ultrasensitive colorimetric fluorescent probe for carbon monoxide detection in living cells. Photochemical & Photobiological Sciences, 2019, 18, 1851-1857. （IF=3.1，共同通讯作者，3区）

51.Pan Jia, Dongmei Liu, Zihan Zhuang, Caiyun Liu, Zilu Li, Chen Yu, Yanan Chen, Hanchuang Zhu, Xue Zhang, Yamin Yu, Baocun Zhu, Wenlong Sheng. Dicyanoisophorone-Derived Near-Infrared Fluorescent Probe for Ultrasensitive Detection of Peroxynitrite in Living Cells and Zebrafish. Industrial & Engineering Chemistry Research. 2019, 58, 19778-19784. （IF=4.2，共同通讯作者，3区）

52.Shanshan Liu, Wenlong Sheng, Yun Li, Shanshan Zhang, Jingjing Zhu, Huimin Gao, Lihua Yan, Zhimin Wang, Lu Gao, Mei Zhang. Chemical constituents from Alismatis Rhizoma and their anti-inflammatory activities in vitro and in vivo. Bioorganic Chemistry,2019, 92, 103226. （IF=5.1，共同第一作者，1区）

53.Caiyun Liu, Xue Zhang, Zilu Li, Yanan Chen, Zihan Zhuang, Pan Jia, Hanchuang Zhu, Yamin Yu, Baocun Zhu, Wenlong Sheng. Novel Dimethylhydrazine-Derived Spirolactam Fluorescent Chemodosimeter for Tracing Basal Peroxynitrite in Live Cells and Zebrafish. Journal of Agricultural and Food Chemistry. 2019, 67, 6407-6413. （IF=6.1，共同通讯作者，1区）

54.Zilu Li, Caiyun Liu,  Chen Yu, Yanan Chen, Pan Jia, Hanchuang Zhu, Xue Zhang, Yamin Yu, Baocun Zhu, Wenlong Sheng. A highly selective and sensitive red-emitting fluorescent probe for visualization of endogenous peroxynitrite in living cells and zebrafish. Analyst. 2019, 144, 3442-3449. （IF=4.2，共同通讯作者，2区）

55.Zilu Li, Caiyun Liu,  Chen Yu, Ruifang Yuan, Pan Jia, Zuokai Wang, Qingxia Duan, Hanchuang Zhu, Baocun Zhu, Wenlong Sheng. A water-soluble and highly specific fluorescent probe for imaging thiophenols in living cells and zebrafish. New Journal of Chemistry, 2019, 43, 6746-6752. （IF=3.3，共同通讯作者，3区）

56.Zilu Li, Chen Yu, Yanan Chen, Zihan Zhuang, Bin Tian, Caiyun Liu, Pan Jia, Hanchuang Zhu, Wenlong Sheng, Baocun Zhu. A novel water-soluble fluorescent probe with ultra-sensitivity over a wider pH range and its application for differentiating cancer cells from normal cells. Analyst, 2019, 144, 6975. （IF=4.2，共同通讯作者，2区）

57.Zilu Li, Chen Yu, Yanan Chen, Caiyun Liu, Pan Jia, Hanchuang Zhu, Xue Zhang, Wenlong Sheng, Baocun Zhu. A novel ratiometric fluorescent probe for highly sensitive and selective detection of peroxynitrite and its application for tracing endogenous peroxynitrite in live cells. Analytical Methods, 2019, 11, 5699. （IF=3.1，共同通讯作者，3区）

58.Hanchuang Zhu, Caiyun Liu, Ruifang Yuan, Ruikang Wang, Hanming Zhang, Zilu Li, Pan Jia, Baocun Zhu, Wenlong Sheng. A simple highly specific fluorescent probe for simultaneous discrimination of cysteine/homocysteine and glutathione/hydrogen sulfide in living cells and zebrafish using two separated fluorescence channels under single wavelength excitation. Analyst, 2019, 144, 4258-4265. （IF=4.2，共同通讯作者，2区）

59.Hanchuang Zhu, Hanming Zhang, Changxu Liang, Caiyun Liu, Pan Jia, Zilu Li, Yamin Yu, Xue Zhang, Baocun Zhu, Wenlong Sheng. A novel highly sensitive fluorescent probe for bioimaging biothiols and its applications in distinguishing cancer cells from normal cells. Analyst, 2019, 144, 7010. （IF=4.2，共同通讯作者，2区）

60.Liwen Han, Wenlong Sheng, Xiaobin Li, Attila Sik, Houwen Lin, Kechun Liu, Lizhen Wang. Novel carbohydrate modified berberine derivatives: synthesis and in vitro anti-diabetic investigation. MedChemComm, 2019, 10, 598. （共同第一作者）

61.Xue Zhang, Yanan Chen, Caiyun Liu, Zihan Zhuang, Zilu Li, Pan Jia, Hanchuang Zhu, Yamin Yu, Baocun Zhu, Wenlong Sheng. A novel hexahydropyridazin-modified rhodamine fluorescent probe for tracing endogenous/exogenous peroxynitrite in live cells and zebrafish. Dyes and Pigments, 2019, 170, 107573. （IF=4.5，共同通讯作者，1区）

62.Pan Jia, Zihan Zhuang, Caiyun Liu, Zuokai Wang, Qingxia Duan, Zilu Li, Hanchuang Zhu, Bin Du, Baocun Zhu, Wenlong Sheng, Baotao Kang. A highly specific and ultrasensitive p-aminophenylether-based fluorescent probe for imaging native HOCl in live cells and zebrafish. Analytica Chimica Acta, 2019, 1052, 131-136. （IF=6.2，共同通讯作者，1区）

63.Wenlong Sheng, Weiyi Chen, XionglYang i, Yongmei Zhong, Shijun Weng. Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells. PLoS One, 2015, 10:e0117967. （IF=3.7，第一作者，3区）

64.任季禹，杨凯，靳梦，张姗姗，于妙慧，辛秀秀，李晓彬，刘可春，张云，臧传宝，盛文龙，不同干燥与提取方式处理的人源胎盘防治贫血活性差异研究，药物评价研究，2022, 45, 8,1592-1596. （通讯作者，核心期刊）

65.盛文龙，武云，刘发生，李娟娟，靳梦，何秋霞，韩兵，黄金栋，韩利文，刘可春，黑蒜促进血管生成作用，食品工业科技，2018, 39, 14, 301-305. （第一作者，核心期刊）

发表其他学术论文25篇

1.Hanchuang Zhu, Mengyuan Liu, Caiyun Liu, Kun Wang, Miaohui Yu, Xinke Li, Wenlong Sheng , Baocun Zhu, Dual-mode optical chemodosimeter for detecting copper ions in the environment, food, and living organisms with smartphone, Chemical Engineering Journal, 2023, 471, 144442 （IF=15.1，1区）

2.Xiaohui Zhang, Caiyun Liu, Hanchuang Zhu, Kun Wang, Mengyuan Liu, Xinke Li, Lixue Ma, Miaohui Yu, Wenlong Sheng, Baocun Zhu, A novel benzothiazolin-based fluorescent probe for hypobromous acid and its application in environment and biosystems, Talanta, 2023, 266, 124969 （IF=6.1，1区）

3.Mengyuan Liu, Hanchuang Zhu, Yikun Fang, Caiyun Liu, Kun Wang, Xiaohui Zhang, Xinke Li, Lixue Ma, Miaohui Yu, Wenlong Sheng, Baocun Zhu, 3D-printed colorimetric copper ion detection kit and portable fluorescent sensing device using smartphone based on ratiometric fluorescent probes,  Analytica Chimica Acta, 2023, 1286, 341980. （IF=6.2， 1区）

4.Hanchuang Zhu, Mengyuan Liu, Caiyun Liu, Xinke Li, Kun Wang, Miaohui Yu, Wenlong Sheng, Baocun Zhu, A reversible and ratiometric fluorescent probe based on rhodol derivative with an ESIPT unit for monitoring copper ion content and in situ evaluation of related drugs in cells, Bioorganic Chemistry, 2023, 139, 106733（IF=5.1，1区）

5.Lizhen Wang, Xiaolan Liu, Changqing Zhang, Xiqiang Chen, Wenlong Sheng, Peihai Li, Dawei Qin, Fang Wang, Novel amphiphilic hydroxyethyl starch-based nanoparticles loading camptothecin exhibit high anticancer activity in HepG2 cells and zebrafish, Colloids and Surfaces B- Biointerfaces, 2023, 224, 113215 （IF=5.8，2区）

6.Dawei Qin, Fang Wang, Wenlong Sheng, Shuhua Chang, Hongdong Duan, Lizhen Wang, Nanogel fabricated from oxidized sodium alginate and hydrophilic modified chitosan exhibits great potential as pH responsive drug delivery system, Journal of the Iranian Chemical Society, 2023, 20, 921–930.（IF=2.4，4区）

7.Qingyu Ren, Xin Jiang, Yam Nath Paudel, Xin Gao, Daili Gao, Pengyu Zhang, Wenlong Sheng, Xueliang Shang, Kechun Liu, Xiujun Zhang, Meng Jin, Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson’s disease like pathology in Zebrafish, Journal of Ethnopharmacology, 2022, 292, 115234, (IF=5.4，1区)

8.Hanchuang Zhu, Wenlong Sheng, Caiyun Liu, Hanming Zhang, Changxu Liang， Xue Zhang, Kun Wang, Xiwei Li, Yamin Yu, Dawei Fan, BaocunZhu. Rational design of a fluorescent probe and its applications of imaging and distinguishing between exogenous and endogenous H2S in living cells. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy. 2022, 266, 120407. （IF=4.4，2区）

9.Xiwei Li, Na Gao, Caiyun Liu, Miaohui Yu, Xiaodi Rong, Yan Zhang, Meijun Su, Xin Wang, Hanchuang Zhu, Kun Wang, Yilin Liu, Wenlong Sheng, Baocun Zhu, A melatonin-based targetable fluorescent probe activated by hydrogen peroxide for tumor cells screening, Sensors and Actuators B- Chemical, 2022, 353, 131051. （IF=8.4，1区）

10.Xiwei Li, Caiyun Liu, Na Gao, Wenlong Sheng, Baocun Zhu, A melatonin-based targetable fluorescent probe for screening of tumor cells and real-time imaging of glutathione fluctuations in tumor cells, Chinese Chemical Letters, 2022, 33, 2527-2531（IF=9.1，1区）

11.Weiyi Chen , Xu Han , Lingjie Cui , Chenxi Yu , Wenlong Sheng , Jun Yu , Fei Yuan , Yongmei Zhong , Xiongli Yang , Shijun Weng. Cell-Subtype-Specific Remodeling of Intrinsically Photosensitive Retinal Ganglion Cells in Streptozotocin-Induced Diabetic Mice. Diabetes. 2021; 70(5): 1157-1169. (IF=7.7，1区)

12.Xiaodi Rong, Caiyun Liu , Mingzhu Li, Hanchuang Zhu, Yan Zhang, Meijun Su, Xin Wang, Xiwei Li, Kun Wang, Miaohui Yu, Wenlong Sheng, Baocun Zhu, An Integrated Fluorescent Probe for Ratiometric Detection of Glutathione in the Golgi Apparatus and Activated Organelle-Targeted Therapy, Analytical Chemistry. 2021, 93, 16105-16112.（IF=7.4，1区）

13.Li Huang, Wenlong Sheng, Lizhen Wang, Xia Meng, Hongdong Duan, Liqun Chi, A novel coumarin-based colorimetric and fluorescent probe for detecting increasing concentrations of Hg2+ in vitro and in vivo, RSC Advances, 2021,11, 23597-23606.（IF=3.9，3区）

14.Kun Wang, Yilin Liu, Caiyun Liu, Hanchuang Zhu, Xiwei Li, Fenfen Zhang, Na Gao, Xiangming Pang, Wenlong Sheng, Baocun Zhu, A simple pyridine-based highly specific fluorescent probe for tracing hypochlorous acid in lysosomes of living cells, New Journal of Chemistry, 2021, 45, 14548-14553. （IF=3.3，3区）

15.Meng Jin, Ning Li, Wenlong Sheng, Xiuna Ji, Xiu Liang, Biao Kong, Penggang Yin, Yong Li, Xingshuang Zhang, Kechun Liu. Toxicity of different zinc oxide nanomaterials and dose-dependent onset and development of Parkinson's disease-like symptoms induced by zinc oxide nanorods. Environment International, 2021, 146, 106179. (IF=11.8，1区）

16.Xue Wang, Xueliang Yang, Kechun Liu, Wenlong Sheng, Qing Xia, Rongchun Wan, Xiqiang Chen, Yun Zhang. Effects of streptozotocin on pancreatic islet β-cell apoptosis and glucose metabolism in zebrafish larvae. Fish Physiology and Biochemistry, 2020, 46, 1025–1038. (IF=2.9，3区）

17.Xuanming Zhang, Liwen Han, Wenlong Sheng, Xiaobin Li, Shanshan Zhang, Qing Xia, Guan’e Yang, Kechun Liu. Two novel holostane-type glycosides from the viscera of sea cucumber Apostichopus japonicus with antitumor activities, Revue Roumaine de Chimie, 2020, 64(4), 353-359. （IF=0.5，4区）

18.Meng Jin, Xiuna Ji, Baoyue Zhang, Wenlong Sheng, Rongchun Wang, Kechun Liu. Synergistic effects of Pb and repeated heat pulse on developmental neurotoxicity in zebrafish. Ecotoxicology and Environmental Safety, 2019, 172, 460–470. （IF=6.8，1区）

19.Xuanming Zhang, Liwen Han, Wenlong Sheng, Xiaobin Li, Shanshan Zhang, Jinglan Guo, Houwen Lin, Kechun Liu. Two novel non-holostane type glycosides from the viscera of sea cucumber Apostichopus japonicas. Journal of Asian natural products research. 2019, 22, 329,337. （IF=1.7，4区）

20.Meng Jin, Wenlong Sheng, Liwen Han, Qiuxia He, Xiuna Ji, Kechun Liu. Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. Fish & Shellfish Immunology, 2018, 83, 26-36. （IF=4.7，1区）

21.Zuokai Wang, Zhuofan Geng, Ziyang Zhao, Wenlong Sheng, Caiyun Liu, Xiaoyu Lv, Qiuxia He, Baocun Zhu. A highly specific and sensitive ratiometric fluorescent probe for carbon monoxide and its bioimaging applications. New Journal of Chemistry, 2018, 42, 14417-14423. （IF=3.3，3区）

22.Qiuju Jiang, Guofeng Li, Huixia Zhao, Wenlong Sheng, Lan Yue, Min Su, Shijun Weng, Leanne Lai-Hang Chan, Qifa Zhou, Mark S. Humayun, Weibao Qiu , and Hairong Zheng. Temporal Neuromodulation of Retinal Ganglion Cells by Low-Frequency Focused Ultrasound Stimulation. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2018, 26 (5), 969-976. （IF=4.0，2区）

23.Qinqin Deng, Wenlong Sheng, Gong Zhang, Shijun Weng, Xiongli Yang, Yongmei Zhong. Signalling mechanism for somatostatin receptor 5-mediated suppression of AMPA responses in rat retinal ganglion cells. Neuropharmacology, 2016, 107, 215e226. （IF=4.7，2区）

24.Marquis T. Walker, Alan Rupp, Rebecca Elsaesser, Ali D. Güler, Wenlong Sheng, Shijun Weng, David M. Berson, Samer Hattar, Craig Montell. RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells. Molecular Biology of the Cell, 2015, 26 3671-3678. （IF=3.3，3区）

25.Chao Zheng, Qinqin Deng, Leilei Liu, Mengya Wang, Gong Zhang, Wenlong Sheng, Shijun Weng, Xiongli Yang, Yongmei Zhong. Orexin-A differentially modulates AMPA-preferring responses of ganglion cells and amacrine cells in rat retina. Neuropharmacology, 2015, 93, 80-93. （IF=4.7，2区）

授权国家发明专利：

1.一种基于双香豆素衍生物的过氧化亚硝酸盐荧光探针、制备方法与应用，国家发明专利，已授权。

2.一种快速高选择性次溴酸荧光探针、制备方法与应用，国家发明专利，已授权。

3.一种快速响应的过氧化亚硝酸盐荧光探针、制备方法与应用，国家发明专利，已授权。

4.一种超灵敏亚铁离子荧光探针、制备方法与应用，国家发明专利，已授权。

5.一种氨基配位型高选择性汞离子荧光探针、制备方法与应用，国家发明专利，已授权。

6.一种高选择性灵敏检测镍离子荧光探针、制备方法与应用，国家发明专利，已授权。

7.一种快速评价化合物急性毒性的装置及其工作方法，国家发明专利，已授权。

8.一种三氮唑糖修饰的小檗碱盐衍生物及其制备方法和用途，国家发明专利，已授权。

9.一种斑马鱼老年疾呆模型的建立方法及应用，国家发明专利，已授权。

10.利用鳕鱼内脏制备高纯度海产多不饱和脂肪酸磷脂的方法，国家发明专利，已授权。

11.一种非海参烷型海参皂苷及其制备方法与应用，国家发明专利，已授权。

参与制定并发布的团体标准：

1. 基于斑马鱼模型的保健食品有助于消化功能快速评价方法，T/SNHFA 005-2020

2. 基于斑马鱼模型的保健食品辅助改善营养性贫血功能快速评价方法，T/SNHFA 006-2020

3. 基于斑马鱼模型的保健食品有助于维持血脂健康水平功能快速评价方法，T/SNHFA 007-2020

4. 基于斑马鱼模型的保健食品有助于增强免疫力功能快速评价方法，T/SNHFA 008-2020

5. 基于斑马鱼模型的保健食品急性毒性安全评价方法，T/SNHFA 009-2020

6. 基于斑马鱼模型的保健食品肾毒性快速评价方法，T/SNHFA 010-2020

获奖：

1. 济南市优秀自然科学学术成果二等奖，1/5

2. 山东省海洋科技创新奖二等奖，7/9

3. 第九届山东省大学生科技创新大赛校级三等奖，1/2指导老师

人才称号和荣誉：

济南市高层次人才（E类）

2020年度山东省科学院生物研究所所嘉奖

2019年度山东省科学院生物研究所所嘉奖

2018年度山东省科学院院嘉奖

2017年度山东省科学院院嘉奖